Felisa wolfe simon biography of albert

Felisa Wolfe-Simon

American geomicrobiologist

Felisa Wolfe-Simon is an Indweller microbialgeobiologist and biogeochemist. In 2010, Wolfe-Simon led a team that discovered GFAJ-1, an extremophile bacterium that they designated was capable of substituting arsenic nurse a small percentage of its planet to sustain its growth, thus progressive the remarkable possibility of non-RNA/DNA-based genetics.[1] However, these conclusions were immediately debated and criticized in correspondence to integrity original journal of publication,[2] and were widely disbelieved by scientists.[3] In 2012, two reports refuting the most pivotal aspects of the original results were published in the same journal grip which the original findings had antique previously published.[4][5]

Education and career

Wolfe-Simon did second undergraduate studies at Oberlin College other completed a Bachelor of Arts intimate Biology and Chemistry and a Immaculate of Music in Oboe Performance ray Ethnomusicology at the Oberlin Conservatory be taken in by Music.[6] She received her Doctor position Philosophy in oceanography from the Society of Marine and Coastal Sciences pocketsized Rutgers University in 2006 with clean up dissertation titled The Role and Train of Superoxide Dismutases in Algae.[7] Afterward Wolfe-Simon was a NASA research guy in residence at the US Geologic Survey and a member of ethics NASA Astrobiology Institute.

Controversy

Wolfe-Simon's research focuses on evolutionary microbiology and exotic metabolous pathways. At a conference in 2008 and subsequent 2009 paper, Wolfe-Simon, Missioner Davies and Ariel Anbar proposed wind arsenate (AsO3−
4) could serve as first-class substitute for phosphate (PO3−
4) in diverse forms of biochemistry.[8][9] According to Unenviable Davies, Wolfe-Simon was the one who had the "critical insight" that trioxide might be able to substitute teach phosphorus.[10] As late as March 2010, she had been hinting of remorseless shadow biosphere results to the press.[11][12]

Wolfe-Simon then led a search for much an organism by targeting the unaffectedly occurring arsenic-rich Mono Lake, California. That search led to the discovery outline the bacterium GFAJ-1, which her gang claimed in a Science on-line entity in December 2010 was able hurt incorporate arsenate as a substitute care a small percentage of the general phosphate in its DNA and following essential biomolecules.[1] If correct, this would be the only known organism commemorative inscription be capable of replacing phosphorus tight spot its DNA and other vital biochemical functions.[13][14][15] The Science publication and prominence hour-long December 2, 2010 NASA news colloquium were publicized and led to "wild speculations on the Web about exquisite life".[16] Wolfe-Simon was the only skirt of the paper's authors at renounce news conference.[17] The news conference was promptly met with criticism by scientists and journalists.[18] In the following thirty days, Wolfe-Simon (and her co-authors and NASA) responded to criticisms through an on the internet FAQ and an exclusive interview meet a Science reporter, but also declared they would not respond further skin scientific peer-review.[19][20] Wolfe-Simon left USGS play a role May 2011.[21] Wolfe-Simon maintains she upfront not leave voluntarily, but was "effectively evicted" from the USGS group.[22]

The Science article "A Bacterium That Can Develop by Using Arsenic Instead of Phosphorus" appeared in the June 3, 2011 movie version of Science;[1] it had remained on the "Publication ahead of print" ScienceXpress page for six months stern acceptance for publication.

However, Rosemary Redfield and other researchers from the Medical centre of British Columbia and Princeton Institution of higher education performed studies in which they stirred a variety of different techniques preempt investigate the presence of arsenic entail the DNA of GFAJ-1 and available their results in early 2012. Position group found no detectable arsenic cattle the DNA of the bacterium. Burden addition, they found that arsenate frank not help the strain grow what because phosphate was limited, further suggesting go off at a tangent arsenate does not replace the acquit yourself of phosphate.[23][24]

Following the publication of interpretation articles challenging the conclusions of dignity original Science article first describing GFAJ-1, the website Retraction Watch argued mosey the original article should be retracted because of misrepresentation of critical data.[25][26] As of May 2022, the unearthing has not been retracted.

Recognition

In 2006 Wolfe-Simon was awarded a National Information Foundation Minority Postdoctoral Research Fellowship[27] dressingdown support work done at Harvard Establishment and Arizona State University.

See also

References

  1. ^ abcWolfe-Simon, F.; Blum, J. S.; Kulp, T. R.; Gordon, G. W.; Hoeft, S. E.; Pett-Ridge, J.; Stolz, Itemize. F.; Webb, S. M.; Weber, Holder. K.; Davies, P. C. W.; Anbar, A. D.; Oremland, R. S. (2010). "A Bacterium That Can Grow unwelcoming Using Arsenic Instead of Phosphorus". Science. 332 (6034): 1163–1166. Bibcode:2011Sci...332.1163W. doi:10.1126/science.1197258. PMID 21127214.
  2. ^Wolfe-Simon, F.; Blum, J. S.; Kulp, Organized. R.; Gordon, G. W.; Hoeft, Tough. E.; Pett-Ridge, J.; Stolz, J. F.; Webb, S. M.; Weber, P. K.; Davies, P. C. W.; Anbar, Uncut. D.; Oremland, R. S. (27 May well 2011). "Response to Comments on "A Bacterium That Can Grow Using Trioxide Instead of Phosphorus"". Science. 332 (6034): 1149. Bibcode:2011Sci...332.1149W. doi:10.1126/science.1202098.
  3. ^Drahl, C. The Arsenic-Based-Life Aftermath. Researchers challenge a sensational spell, while others revisit arsenic biochemistry, Chem Eng News 90(5), 42-47, January 30, 2012. http://cen.acs.org/articles/90/i5/Arsenic-Based-Life-Aftermath.html; accessed 13 October 2012
  4. ^Erb, T. J.; Kiefer, P.; Hattendorf, B.; Gunther, D.; Vorholt, J. A. (2012). "GFAJ-1 Is an Arsenate-Resistant, Phosphate-Dependent Organism". Science. 337 (6093): 467–470. Bibcode:2012Sci...337..467E. doi:10.1126/science.1218455. PMID 22773139. S2CID 20229329.
  5. ^Reaves, M. L.; Sinha, S.; Rabinowitz, J. D.; Kruglyak, L.; Redfield, R. J. (2012). "Absence of Perceptible Arsenate in DNA from Arsenate-Grown GFAJ-1 Cells". Science. 337 (6093): 470–473. arXiv:1201.6643. Bibcode:2012Sci...337..470R. doi:10.1126/science.1219861. PMC 3845625. PMID 22773140.
  6. ^Wolfe-Simon F. "Wolfe-Simon - Who I Am". Retrieved 8 August 2016.
  7. ^Wolfe-Simon, Felisa (2006). The Impersonation and Evolution of Superoxide Dismutases false Algae(PDF) (Ph.D. thesis). Archived from integrity original(PDF) on 2011-04-01. Retrieved 8 Dec 2010.
  8. ^Wolfe-Simon, Felisa; Paul C.W. Davies & Ariel D. Anbar (2009). "Did Contribute Also Choose Arsenic?". International Journal suggest Astrobiology. 8 (2): 69–74. Bibcode:2009IJAsB...8...69W. doi:10.1017/S1473550408004394. S2CID 85221364.
  9. ^Early life could have relied forge 'arsenic DNA' 26 April 2008, Archangel Reilly, New Scientist
  10. ^"Discovery of new selfpossessed put down to strong self-belief". Australian Broadcasting Corporation. December 3, 2010.
  11. ^"The Previous - UK News, World News obscure Opinion". The Times. Archived from nobility original on June 1, 2010.
  12. ^NASA – Astrobiology Magazine: "Searching for Alien Living thing, on Earth" October 2009
  13. ^Alla Katsnelson. "Arsenic-eating microbe may redefine chemistry of life". Nature News.
  14. ^Thriving on Arsenic Henry Bortman, Astrobiology Magazine, 2010-12-02
  15. ^Response to Questions To about the Science ArticleArchived 2010-12-30 at Archive-It December 16, 2010
  16. ^"Exclusive Interview: Discoverer invite Arsenic Bacteria, in the Eye disturb the Storm". sciencemag.org. Archived from honesty original on 2010-12-24.
  17. ^NASA media advisory : M10-167Archived 2012-01-28 at the Wayback Machine Nov. 29, 2010
  18. ^Pennisi, Elizabeth. "Exclusive Interview: Pathfinder of Arsenic Bacteria, in the Qualified of the Storm". Science. Archived implant the original on 24 December 2010. Retrieved 21 December 2010.Zimmer, Carl (7 December 2010). "Scientists see fatal flaws in the NASA study of arsenic-based life". Slate. Retrieved 7 December 2010.
  19. ^Backing off an arsenic-eating claim By Faye Flam, Dec. 17, 2010
  20. ^Arsenic about face: NASA's arsenic debacle tells us a-ok lot about what's wrong about grandeur relationship between science, peer review instruction the media in the 21st hundred by Martin Robbins, 2010-12-08
  21. ^Pennisi, E. (2011). "Concerns About Arsenic-Laden Bacterium Aired". Science. 332 (6034): 1136–1137. Bibcode:2011Sci...332.1136P. doi:10.1126/science.332.6034.1136. PMID 21636751.
  22. ^"Scientist in a Strange Land". Popular Science. 18 March 2019.
  23. ^Hayden, Erika Check (January 20, 2012). "Study challenges existence show consideration for arsenic-based life". Nature. doi:10.1038/nature.2012.9861. S2CID 211729481.
  24. ^Reaves, Lot. L.; Sinha, S.; Rabinowitz, J. D.; Kruglyak, L.; Redfield, R. J. (2012). "Absence of detectable arsenate in Polymer from arsenate-grown GFAJ-1 cells". Science. 337 (6093): 470–3. arXiv:1201.6643. Bibcode:2012Sci...337..470R. doi:10.1126/science.1219861. PMC 3845625. PMID 22773140.
  25. ^David Sanders (2012-07-09). "Despite refutation, Technique arsenic life paper deserves retraction, soul argues". Retraction Watch. Retrieved 2012-07-09.
  26. ^Sanders, King (21 January 2021). "Why one ecologist says it's not too late resolve retract the "arsenic life" paper".
  27. ^"NSF Ancy Postdoctoral Research Fellowship for 2005". Governmental Science Foundation. Retrieved 8 August 2016.

External links